Sulfuric Acid → HCID 21270730, compound

HRID 1193927Notes

Reaction equation

HRID 1193927 reaction equation
[CH2:1]([O:3][C:4]1[N:5]([C:18]2[CH:23]=[C:22]([O:24]C(C)C)[C:21]([Cl:28])=[CH:20][C:19]=2[F:29])[C:6](=[O:17])[CH:7]=[C:8]([C:10]([F:16])([F:15])[C:11]([F:14])([F:13])[F:12])[N:9]=1)[CH3:2].S(=O)(=O)(O)O>>[CH2:1]([O:3][C:4]1[N:5]([C:18]2[CH:23]=[C:22]([OH:24])[C:21]([Cl:28])=[CH:20][C:19]=2[F:29])[C:6](=[O:17])[CH:7]=[C:8]([C:10]([F:16])([F:15])[C:11]([F:12])([F:13])[F:14])[N:9]=1)[CH3:2]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 21270731HCID 21270731, compound

Product 1

HCID 21270730HCID 21270730, compound

Procedure

using 2-ethoxy-1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-pentafluoroethyl-6(1H)-pyrimidinone with concentrated sulphuric acid at 0° C. during 1.5 minutes there is obtained 2-ethoxy-1-(4-chloro-2-fluoro-5-hydroxyphenyl)-4-pentafluoroethyl-6(1H)-pyrimidinone, m.p. 117°-120° C.;

Workup

  1. customat 0° C.
  2. customduring 1.5 minutes

Sources & evidence

ORD record
ord-140a9a0b3d184750a52b34af58ee66bd
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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