Sulfuric Acid → 1-(4-chloro-2-fluoro-5-hydroxyphenyl)-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone

HRID 1193930Notes

Reaction equation

[Cl:1][C:2]1[C:7]([O:8]C(C)C)=[CH:6][C:5]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[N:14]=[C:13]2[O:23][CH2:24][CH2:25][CH3:26])=[C:4]([F:27])[CH:3]=1.S(=O)(=O)(O)O>>[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:20])([F:22])[F:21])[N:14]=[C:13]2[O:23][CH2:24][CH2:25][CH3:26])=[C:4]([F:27])[CH:3]=1

Participants

Reactant 2

HCID 1118Sulfuric Acid

HCID 212706991-(4-chloro-2-fluoro-5-isopropoxyphenyl)-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone

Product 1

HCID 212707161-(4-chloro-2-fluoro-5-hydroxyphenyl)-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone

Procedure

using 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone with concentrated sulphuric acid during 2 minutes at 0° C. there is obtained 1-(4-chloro-2-fluoro-5-hydroxyphenyl)-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 122°-123° C.

Workup

customduring 2 minutes
customat 0° C.

Sources & evidence

ORD record: ord-83840de5a43e496c9acce5f0fb416ff8
Source dataset: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04812164

Reaction notes

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