Sulfuric Acid → 2-ethoxy-1-(4-bromo-2-fluoro-5-hydroxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone

HRID 1193933Notes

Reaction equation

HRID 1193933 reaction equation
[CH2:1]([O:3][C:4]1[N:5]([C:15]2[CH:20]=[C:19]([O:21]C(C)C)[C:18]([Br:25])=[CH:17][C:16]=2[F:26])[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[N:9]=1)[CH3:2].S(=O)(=O)(O)O>>[CH2:1]([O:3][C:4]1[N:5]([C:15]2[CH:20]=[C:19]([OH:21])[C:18]([Br:25])=[CH:17][C:16]=2[F:26])[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:11])[F:12])[N:9]=1)[CH3:2]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 21270761HCID 21270761, compound

Product 1

HCID 212707472-ethoxy-1-(4-bromo-2-fluoro-5-hydroxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone

Procedure

using 2-ethoxy-1-(4-bromo-2-fluoro-5-isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone with concentrated sulphuric acid during 2 minutes at 0° C. there is obtained 2-ethoxy-1-(4-bromo-2-fluoro-5-hydroxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 160°-161° C.

Workup

  1. customduring 2 minutes
  2. customat 0° C.

Sources & evidence

ORD record
ord-85621e2ba43c4bc697059f0c21e0eb3e
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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