Phosphorus oxychloride → HCID 21270725, compound

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Reaction Steps

using isopropyl 2-chloro-5-[3,6-dihydro-2,6-dioxo-5-fluoro-4-trifluoromethyl-1(2H) -pyrimidinyl]-4-fluorobenzoate with phosphorus oxychloride and pyridine within 1 hour at room temperature and thereafter for 1 hour at 60° C. there is obtained isopropyl 2-chloro-5-[2-chloro-5-fluoro-6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]4-fluorobenzoate, 1H-NMR (CDCl3, 60 MHz): 7.88 ppm (d,1H), 7.47 ppm (d,1H), 5.30 ppm (m,1H), 1.41 ppm (d,6H);

Provenance & Evidence