Trimethylsilylacetylene → HCID 178504177, compound

Participants

Reaction Steps

A mixture of 500 mg (1,9 mmol) 6-brom-2,3-dihydroxy-7-nitroquinoxaline (ex. 1) in 10 ml dry dimethylformamide and 20 ml dry triethylamine is added 4 mg palladium(II)acetate, 8 mg triphenylphosphine and 600 l (4,3 mmol) trimethylsilylacetylene. The mixture is refluxed for 2.5 h under nitrogen. After cooling to room temperature, the reaction mixture is evaporated in vacuo. The residue is stirred with water, filtered and washed with water to give 500 mg of a crude product. The crude product is dissolved in ethyl acetate and purified by column chromatography (silica gel) to give 400 mg (70%) of 2,3-dihydroxy-6-trimethylsilylethynyl-7-nitroquinoxaline.

Provenance & Evidence