Dimethyl Sulfoxide → HCID 14050295, compound

HRID 1193987Notes

Reaction equation

[Cl:1][C:2]1[C:3]([OH:18])=[C:4]([C:9]([C:11]2[CH:16]=[CH:15][C:14](F)=[CH:13][CH:12]=2)=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1.C[S:20]([CH3:22])=O>>[CH2:22]([S:20][C:14]1[CH:15]=[CH:16][C:11]([C:9]([C:4]2[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[C:3]=2[OH:18])=[O:10])=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 679Dimethyl Sulfoxide

HCID 14050294HCID 14050294, compound

Product 1

HCID 14050295HCID 14050295, compound

Conditions

Temperature: 100 °C

Procedure

The residue is dissolved with 200 ml of dimethyl sulphoxide, 32 g of (3,5-dichloro-2-hydroxyphenyl)-(4-fluorophenyl)methanone are added and the mixture is heated to 100° C. for 8 hours under argon.

Workup

additionare added

Sources & evidence

ORD record: ord-e99d231af1d14b4a80511a0f5ee9ef62
Source dataset: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04812467

Reaction notes

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