Toluene → HCID 14156811, compound

Participants

Reaction Steps

153.2 g (0.60 mole) of N-(2,4-dichlorophenacyl)imidazole and 53.0 g (0.705 mole) of 3-amino-1-propanol are suspended or dissolved in 400 mol of toluene, and the mixture is heated under reflux with a water trap until no more water of reaction separates out. The reaction solution is then washed 3 times with water, the organic phase is dried with sodium sulfate and, after the solvent has been evaporated off, 179 g of 1-(2-(2,4-dichlorophenyl)-2-(3-hydroxypropylimino)ethyl)-1H-imidazole are obtained as a highly viscous oil. (Yield: 95.6%).

Provenance & Evidence