Benzylamine → Benzeneacetamide, 4-hydroxy-N-(phenylmethyl)-

HRID 1193997Notes

Reaction equation

HRID 1193997 reaction equation
CO[C:3](=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.[CH2:13]([NH2:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:13]([NH:20][C:3](=[O:12])[CH2:4][C:5]1[CH:6]=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 518900Benzeneacetic acid, 4-hydroxy-, methyl ester

Product 1

HCID 8376026Benzeneacetamide, 4-hydroxy-N-(phenylmethyl)-

Procedure

A mixture of 80 g of 4-hydroxyphenylacetic acid methyl ester and 51.6 g of benzylamine is brought to 180° C. for 8 hours. The mixture is allowed to return to room temperature and the crystals are filtered off and washed with ethanol and then ethyl ether.

Workup

  1. customto return to room temperature
  2. filtrationthe crystals are filtered off
  3. washwashed with ethanol

Sources & evidence

ORD record
ord-e6cc62827f5340b38cecc8f52ef224c7
Source dataset
uspto-grants-1989_03
Patent number
US04812469

Reaction notes

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