Potassium Hydroxide → HCID 21271270, compound

Participants

Reaction Steps

11.34 g (33.61 mmol) of methyl 4-(7-(3-methyl-5-isoxazolyl)-heptyloxy)-2-thiophenecarboxylate are heated under reflux in 95 ml of ethanol and 45 ml of water, and 2.18 g (38.9 mmol) of KOH, dissolved in 70 ml of water and 46 ml of ethanol, are added dropwise to this solution. After the mixture has been heated under reflux for 3 hours, it is cooled and concentrated, the residue is partitioned between water and ether and the aqueous phase, after acidification to pH 1 with 2N HCl, is extracted several times with ether. The combined organic phases are dried over sodium sulfate/active charcoal and evaporated.

Provenance & Evidence