HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acrylate → HCID 21271730, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acrylate | HCID 8821 | — |
| Reactant | HCID 12606941 | HCID 12606941 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 21271730 | HCID 21271730 | 107.5% |
Reaction Steps
A mixture of 7-(3-chlorophenylsulphamoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride (3.25 g, 9 mmol) (EP No. 0038177-A) and ethyl acrylate (0.91 g, 9 mmol) in THF (8 ml) was heated under reflux for 18 hr. Concentration and chromatography (silica gel, ether) gave ethyl-3-[7-(3-chlorophenylsulphamoyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]propionate as a viscous oil (4.09 g, 98.7%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04812573 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-b7ca57d469d6425eb04fb670feb4b90e |
| Source note | uspto-grants-1989_03 |