Sodium Hydroxide → HCID 21271738, compound

Participants

Reaction Steps

A mixture of ethyl-3-[7-(3-chlorophenylsulphamoyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]propionate (4.08 g) and 10% sodium hydroxide solution (10 ml) in ethanol (10 ml) was stirred at room temperature for one hour. Ethanol was removed in vacuo, water (15 ml) added and the pH was adjusted to 6-7 with 2N HCl. This was extracted with ethylacetate:methanol 4:1 (3×50 ml) and dried (MgSO4). Concentration and crystallization from ethanol-methanol gave 3-[7-(3-chlorophenylsulphamoyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]propionic acid. 1.2H2O, 0.8NaCl (1.61 g, 59%); mpt. 137°-40° C.

Provenance & Evidence