HCID 21271754, compound → HCID 21271725, compound

HRID 1194097Notes

Reaction equation

HRID 1194097 reaction equation
Cl.C([O:4][C:5](=[O:31])[CH2:6][CH2:7][CH2:8][CH2:9][N:10]1[CH2:19][CH2:18][C:17]2[C:12](=[CH:13][C:14]([S:20](=[O:30])(=[O:29])[NH:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=3)=[CH:15][CH:16]=2)[CH2:11]1)C>C(O)C>[Cl:28][C:24]1[CH:23]=[C:22]([NH:21][S:20]([C:14]2[CH:13]=[C:12]3[C:17]([CH2:18][CH2:19][N:10]([CH2:9][CH2:8][CH2:7][CH2:6][C:5]([OH:31])=[O:4])[CH2:11]3)=[CH:16][CH:15]=2)(=[O:29])=[O:30])[CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 1

HCID 21271754HCID 21271754, compound

Product 1

HCID 21271725HCID 21271725, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7-(3-Chlorophenylsulphamoyl)-1,2,3,4-tetrahydroisoquinoline was reacted with ethyl 5-bromovalerate under conditions analogous to those described in Example 2(a). The crude product of the alkylation reaction was then treated with ethereal HCl, and the following ethyl ester hydrochloride was obtained; ethyl-5-[7-(3-chlorophenylsulphamoyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]valerate hydrochloride; mpt. 178°-180° C. (from ethanol).

Sources & evidence

ORD record
ord-c61444ba7adc46bfb4d90b7a97fa6721
Source dataset
uspto-grants-1989_03
Patent number
US04812573

Reaction notes

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