Ethyl 5-bromovalerate → HCID 21271736, compound

HRID 1194098Notes

Reaction equation

HRID 1194098 reaction equation
Cl.[C:2]1([NH:8][S:9]([C:12]2[CH:21]=[C:20]3[C:15]([CH2:16][CH2:17][NH:18][CH2:19]3)=[CH:14][CH:13]=2)(=[O:11])=[O:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O:24][C:25](=[O:31])[CH2:26][CH2:27][CH2:28][CH2:29]Br)C>>[C:2]1([NH:8][S:9]([C:12]2[CH:21]=[C:20]3[C:15]([CH2:16][CH2:17][N:18]([CH2:29][CH2:28][CH2:27][CH2:26][C:25]([OH:31])=[O:24])[CH2:19]3)=[CH:14][CH:13]=2)(=[O:11])=[O:10])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 84580Ethyl 5-bromovalerateHCID 12606919HCID 12606919, compound

Product 1

HCID 21271736HCID 21271736, compound

Procedure

7-(Phenylsulphamoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride was reacted with ethyl-5-bromovalerate under conditions analogous to those described in Example 5 and the resulting ethyl ester was hydrolysed according to the method described in Example 2(b) to give 5-(7-phenylsulphamoyl-1,2,3,4-tetrahydroisoquinolin-2-yl)valeric acid as a colourless microcrystalline solid. mpt. 176°-176.5° C. (acetonitrile/ethanol).

Sources & evidence

ORD record
ord-8fdedd5f5aa04ee78cb429e082336b22
Source dataset
uspto-grants-1989_03
Patent number
US04812573

Reaction notes

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