HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-bromobutyrate → Ethyl 4-[5-phenylsulphonamido-1,2,3,4-tetrahydroisoquinolin-2-yl]butyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-bromobutyrate | HCID 76300 | — |
| Reactant | 5-Phenylsulphonamido-1,2,3,4-tetrahydroisoquinoline hydrochloride | HCID 21271748 | — |
| Product | Ethyl 4-[5-phenylsulphonamido-1,2,3,4-tetrahydroisoquinolin-2-yl]butyrate | HCID 21271751 | — |
Reaction Steps
5-Phenylsulphonamido-1,2,3,4-tetrahydroisoquinoline hydrochloride (2.7 g) was reacted with ethyl 4-bromobutyrate in the manner described in Example 2(a). After elution from a silica column with ethyl acetate:methanol mixtures, the product was recrystallised from ethanol to give ethyl 4-[5-phenylsulphonamido-1,2,3,4-tetrahydroisoquinolin-2-yl]butyrate as a white solid (2.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04812573 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-bf646b4f8fc34e2da77ab3aba5ae5b8f |
| Source note | uspto-grants-1989_03 |