4-Chloroaniline → HCID 12606920, compound

HRID 1194110Notes

Reaction equation

HRID 1194110 reaction equation
C([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][C:8]([S:14](Cl)(=[O:16])=[O:15])=[CH:9][CH:10]=2)[CH2:5]1)(=O)C.[Cl:18][C:19]1[CH:25]=[CH:24][C:22]([NH2:23])=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:25]=[CH:24][C:22]([NH:23][S:14]([C:8]2[CH:7]=[C:6]3[C:11]([CH2:12][CH2:13][NH:4][CH2:5]3)=[CH:10][CH:9]=2)(=[O:15])=[O:16])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 78124-ChloroanilineHCID 126069042-Acetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride

Product 1

HCID 12606920HCID 12606920, compound

Procedure

Using the method described in Example 7, 2-acetyl-7-chlorosulphonyl-1,2,3,4-tetrahydroisoquinoline was reacted with 4-chloroaniline and the product was deacetylated to give 7-(4-chlorophenylsulphamoyl)-1,2,3,4-tetrahydroisoquinoline as the hydrochloride salt.

Sources & evidence

ORD record
ord-434eb3d6846b49bfa92c160a99ac0499
Source dataset
uspto-grants-1989_03
Patent number
US04812573

Reaction notes

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