Sodium Hydroxide → HCID 21271747, compound

HRID 1194111Notes

Reaction equation

HRID 1194111 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:9]([C:12]2[CH:21]=[C:20]3[C:15]([CH2:16][CH2:17][N:18]([CH2:22][CH2:23][CH2:24][C:25]([O:27]CC)=[O:26])[CH2:19]3)=[CH:14][CH:13]=2)(=[O:11])=[O:10])=[CH:4][CH:3]=1.[OH-].[Na+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][S:9]([C:12]2[CH:21]=[C:20]3[C:15]([CH2:16][CH2:17][N:18]([CH2:22][CH2:23][CH2:24][C:25]([OH:27])=[O:26])[CH2:19]3)=[CH:14][CH:13]=2)(=[O:10])=[O:11])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 21271750HCID 21271750, compound

Product 1

HCID 21271747HCID 21271747, compound

Procedure

Ethyl 4-[7-(4-chlorophenylsulphamoyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]butyrate was hydrolysed with sodium hydroxide solution by the method described in Example 2(b) and the product was recrystallised from ethanol to give the title compound, m.p. 210°-210.5° C.

Workup

  1. customthe product was recrystallised from ethanol

Sources & evidence

ORD record
ord-a5c60d0dc4ba46fe9a8cc83e119540c3
Source dataset
uspto-grants-1989_03
Patent number
US04812573

Reaction notes

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