3-(Dimethylamino)prop-2-enenitrile → 3-(2,3-Dichlorophenacylamino)acrylonitrile

Participants

Reaction Steps

20.0 g of 2,3-dichlorophenacylamine hydrochloride and 10.0 g of 3-dimethylaminoacrylonitrile are heated for 1 hour under reflux in 300 ml of ethanol. After cooling it to room temperature, the reaction solution is poured into a mixture of ice/dilute hydrochloric acid. After extraction with ethyl acetate, the combined extracts are dried over sodium sulfate, filtered, and the filtrate is concentrated. The oily residue is purified by column chromatography (silica gel: elution with a 4:1 mixture of toluene/ethyl acetate). M.p. 125°-127° C. IR (solid/KBr) in cm-1 : 3380 (NH), 2200 (CN), 1715 (CO) 1625 (C=C). 1H-NMR (DMSOd6) in ppm: 4.09 (d, J=15 Hz, 1H); 4.46 (d, J=7 Hz, 2H); 7.2 (q, 1H); 7.4 (broad s, 1H); 7.45-7.85 (m, 3H). Mass spectrum: molecular peak at 254.

Provenance & Evidence