HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Propenenitrile, 3-hydroxy- → 3-(2,3-Dichlorophenacylamino)acrylonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Propenenitrile, 3-hydroxy- | HCID 3054073 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | Ethanone, 2-amino-1-(2,3-dichlorophenyl)-, hydrochloride | HCID 22151845 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(2,3-Dichlorophenacylamino)acrylonitrile | HCID 67944094 | — |
Reaction Steps
2 g of 2,3-dichlorophenacylamine hydrochloride, 1 g of 3-hydroxyacrylonitrile, sodium salt, and 20 ml of ethanol are heated for 2 hours under reflux. The reaction mixture is concentrated by evaporation and the oily residue is purified by column chromatography (silica gel; elution with a 4:1 mixture of tolluene/ethyl acetate), affording 3-(2,3-dichlorophenacylamino)acrylonitrile in the cis/trans ratio of 5:1. Melting point: 122°-125° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04812580 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-e8ad255109494e9aaab2f340b8aedb4e |
| Source note | uspto-grants-1989_03 |