Propionic Acid → 1-(2-Furyl)propan-1-one

Temperature

50 °C

In 50 ml of toluene were dissolved 3.7 g (0.05 mole) of propionic acid and 10.26 g (0.06 mole) of monochloroacetic anhydride. To the resulting solution were added 5.36 g (0.065 mole) of 2-methylfuran and 0.71 g of boron trifluoride-diethyl ether complex and the resulting mixture was then stirred at 50° C. for 7 hours. After completion of the reaction, the reaction solution was cooled and washed successively with 5% aqueous sodium carbonate solution and water. The organic layer was concentrated under reduced pressure and the resulting concentrated residue was then purified by silica gel-filled column chromatography to obtain 2.96 g of 2-propionylfuran.

1. customAfter completion of the reaction
2. temperaturethe reaction solution was cooled
3. washwashed successively with 5% aqueous sodium carbonate solution and water
4. concentrationThe organic layer was concentrated under reduced pressure
5. customthe resulting concentrated residue was then purified by silica gel-
6. additionfilled column chromatography

ORD record

ord-2585bff7b5a548d4aeb6da610803c30e

Source dataset

uspto-grants-1989_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04812585