反应详情

温度

50 °C

In 50 ml of toluene were dissolved 4.41 g (0.05 mole) of isobutyric acid, 5.34 g (0.065 mole) of 2-methylfuran and 14.39 g (0.06 mole) of dichloroacetic anhydride. To the resulting solution was added 0.71 g of boron trifluoride-diethyl ether complex and the resulting mixture was then stirred at 50° C. for 3 hours. After completion of the reaction, the reaction solution was cooled and washed successively with 5% aqueous sodium carbonate solution and water. The organic layer was concentrated under reduced pressure and the resulting concentrated residue was then purified by silica gel-filled column chromatography to obtain 6.74 g of 2-isobutyryl-5-methylfuran.

1. additionTo the resulting solution was added 0.71 g of boron trifluoride-diethyl ether complex
2. customAfter completion of the reaction
3. temperaturethe reaction solution was cooled
4. washwashed successively with 5% aqueous sodium carbonate solution and water
5. concentrationThe organic layer was concentrated under reduced pressure
6. customthe resulting concentrated residue was then purified by silica gel-
7. additionfilled column chromatography