Furan → HCID 14473413, compound

Participants

Reaction Conditions

Reaction Steps

In 50 ml of toluene were dissolved 7.31 g (0.05 mole) of 6-methoxyhexanoic acid, 4.43 g (0.065 mole) of furan and 14.39 g (0.06 mole) of dichloroacetic anhydride. To the resulting solution was added 0.71 g of boron trifluoride-diethyl ether complex and the resulting mixture was then stirred at 50° C. for 3 hours. After completion of the reaction, the reaction solution was cooled and washed successively with 5% aqueous sodium carbonate solution and water. The organic layer was concentrated under reduced pressure and the resulting concentrated residue was then purified by silica gel-filled column chromatography to obtain 8.83 g of 2-(6-methoxyhexanoyl)furan.

Provenance & Evidence