Furan → HCID 573556, compound

Participants

Reaction Conditions

Reaction Steps

In 50 ml of toluene were dissolved 9.41 g (0.05 mole) of suberic acid monomethyl ester and 9.83 g (0.0575 mole) of monochloroacetic anhydride. To the resulting solution were added 4.43 g (0.065 mole) of furan and 1.0 g of boron trifluoride-acetic acid complex and the resulting mixture was then stirred at 60° C. for 3 hours. After completion of the reaction, the reaction solution was cooled and washed successively with 5% aqueous sodium carbonate solution and water. The organic layer was concentrated under reduced pressure and the resulting concentrated residue was then purified by silica gel-filled column chromatography to obtain 10.1 g of 2-(7-methoxycarbonyl-1-oxoheptyl)furan.

Provenance & Evidence