HCID 14403640, compound → HCID 14403634, compound

Participants

Reaction Steps

A solution of 31.2 g methyl-1-(4-nitro-3-methylphenyl)methyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylate in tetrahydrofuran-methanol (2:1, 600 mL) is treated with 8.0 g Raney Nickel and placed under an atmosphere of hydrogen at 50 psi for 26 hr. The catalyst is removed by filtration and filtrate is evaporated to give a crisp foam. NMR (CDCl3) 6.77 (s+d,2H,2,6-Ar); 6.60 (d,1H,5-Ar). mp 182°-188° C.

Provenance & Evidence