Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 14457543 | HCID 14457543 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | HCID 14403497 | HCID 14403497 | — |
Reaction Steps
A solution of the product from Example 16 (2.35 g) in 25 mL THF-methanol (2:1) is treated with 10 mL 1N NaOH, stirring 90 min at 25° C. After treatment with 10 mL 1N HCl, the mixture is diluted with 60 mL methanol-water (2:1) and concentrated in vacuo until a thick slurry forms. The slurry is diluted with water and the desired carboxylic acid is collected by filtration. MS (FAB) 468 (M+1); mp 187°-190° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04812462 |
|---|
| Source dataset | uspto-grants-1989_03 |
|---|
| ORD ID | ord-e07393206c654f179a4f8f1190fc2ab0 |
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| Source note | uspto-grants-1989_03 |
|---|
