p-Toluenesulfonic acid monohydrate → HCID 131715885, compound

Participants

Reaction Steps

To a solution of 0.56 g (0.8 mM) of benzhydryl 7β-tritylamino-3-carbamoylmethylthio-3-cephem-4-carboxylate obtained in Example 2(a) in 10 ml of ethyl acetate, 0.18 g (0.96 mM) of p-toluenesulfonic acid monohydrate was added under ice-cooling, and the mixture was stirred for 4 hours. After the reaction, the white crystals which formed were collected by filtration to give 0.392 g of 7β-amino-3-carbamoylmethylthio-3-cephem-4-carboxylic acid benzhydryl ester p-toluenesulfonate.

Provenance & Evidence