Formic Acid → HCID 14256951, compound

Participants

Reaction Conditions

Reaction Steps

Into a 300-ml four-necked flask fitted with a thermometer and a stirrer were charged 35.0 g of 2,4-dichloro-5-iodopyrimidine, 15.0 g of potassium thiocyanate, and 150 ml of formic acid. This reaction mixture was stirred at room temperature (20° C.) for 3 hours. After completion of the reaction, the reaction mixture was poured into a large volume of water and the resulting precipitate was filtered off and dried to obtain crude crystals. Then, these crystals were recrystallized from toluene to obtain 28.5 g (75.4% yield) of 2-chloro-5-iodo-4-thiocyanopyrimidine, m.p. 185°-186.5° C.

Provenance & Evidence