Potassium thiocyanate → HCID 14256956, compound

HRID 1194310Notes

Reaction equation

HRID 1194310 reaction equation
[Br:1][C:2]1[C:3](I)=[N:4][C:5]([I:8])=[N:6][CH:7]=1.[S-:10][C:11]#[N:12].[K+]>C(O)=O>[Br:1][C:2]1[C:3]([S:10][C:11]#[N:12])=[N:4][C:5]([I:8])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 516872Potassium thiocyanateHCID 14407715HCID 14407715, compound

Product 1

HCID 14256956HCID 14256956, compoundYield 82.4%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

In 30 ml of formic acid, a reaction of 4.11 g of 5-bromo-2,4-diiodopyrimidine and 1.17 g of potassium thiocyanate was conducted at room temperature (20° C.) for 5 hours in a similar manner as Synthesis Example 1. Then, the reaction mixture was treated in a similar procedure as Synthesis Example 1, there was obtained a 82.4% yield of 5-bromo-2-iodo-4 thiocyanopyrimidine, m.p. 199°-202° C.

Workup

  1. customwas conducted at room temperature
  2. custom(20° C.)
  3. customfor 5 hours
  4. customas Synthesis Example 1
  5. additionThen, the reaction mixture was treated in a similar procedure as Synthesis Example 1

Sources & evidence

ORD record
ord-dd2812ad6dce473d88b14dbfffd87bf2
Source dataset
uspto-grants-1989_03
Patent number
US04814337

Reaction notes

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