Potassium thiocyanate → HCID 14256957, compound

HRID 1194311Notes

Reaction equation

HRID 1194311 reaction equation
[I:1][C:2]1[N:7]=[C:6](I)[C:5]([I:9])=[CH:4][N:3]=1.[S-:10][C:11]#[N:12].[K+]>C(O)=O>[I:1][C:2]1[N:7]=[C:6]([S:10][C:11]#[N:12])[C:5]([I:9])=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 516872Potassium thiocyanateHCID 14407716HCID 14407716, compound

Product 1

HCID 14256957HCID 14256957, compoundYield 84.7%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

In 150 ml of formic acid, a reaction of 19.0 g of 2,4,5-triiodopyrimidine and 5.0 g of potassium thiocyanate was conducted at room temperature (20° C.) for 3 hours in a similar manner as Synthesis Example 1. Then, the reaction mixture was treated in a similar procedure as Synthesis Example 1, there was obtained a 84.7% yield of 2,5-diiodo-4-thiocyanopyrimidine, m.p. 183°-185° C.

Workup

  1. customwas conducted at room temperature
  2. custom(20° C.)
  3. customfor 3 hours
  4. customas Synthesis Example 1
  5. additionThen, the reaction mixture was treated in a similar procedure as Synthesis Example 1

Sources & evidence

ORD record
ord-c302cfa457ea411abcfb03bfe741a63e
Source dataset
uspto-grants-1989_03
Patent number
US04814337

Reaction notes

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