HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine, 1-(2-chloroethyl)-, hydrochloride → HCID 21269554, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine, 1-(2-chloroethyl)-, hydrochloride | HCID 74826 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2H-Benzimidazole-2-thione, 1,3-dihydro-5-methyl- | HCID 712373 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 21269554 | HCID 21269554 | — |
Reaction Steps
4.87 g (30 mmoles) of 5-methyl-benzimidazoline-2-thione, 6.54 g (35.5 mmoles) of 2-(1-piperidyl)-ethylchloride hydrochloride, 2.78 g (33 mmoles) of sodium hydrogencarbonate are dissolvent in 60 ml of methanol and the mixture is refluxed for 6 hours. The inorganic salt is filtered off, the filtrate is evaporated, and the title compound is precipitated by adding ethyl acetate and hydrochloric ethyl acetate. Weight: 9.32 g (90%). Melting point: 229°-230° C., which does not change after recrystallization from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04814329 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-21e68fd5fa384afca18e68283c69832b |
| Source note | uspto-grants-1989_03 |