Sodium Bicarbonate → HCID 21269560, compound

Participants

Reaction Steps

According to the method described in Example 2 g (25 mmoles) of 5-benzyl-benzimidazoline-2-thione, 4.32 g (30 mmoles) of 2-(dimethylamino)-ethylchloride hydrochloride and 2.55 g of sodium hydrogencarbonate are refluxed in methanol. The salt is filtered off, the filtrate is concentrated and treated with aqueous sodium hydroxide solution and dichloromethane. The organic phase is separated, concentrated and the salt is precipitated by adding hydrochloric ether. 8.15 g (84.8%) of 2-(2-dimethylaminoethylthio)-5-benzyl-benzimidazole dihydrochloride are obtained, which melts at 204° C. after recrystallization from isopropanol.

Provenance & Evidence