Allyl chloride → HCID 2151218, compound

HRID 1194334Notes

Reaction equation

HRID 1194334 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][C:5]2[NH:6][C:7](=[S:9])[NH:8][C:4]=2[CH:3]=1.[CH2:12](Cl)[CH:13]=[CH2:14]>C(O)C>[CH3:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([S:9][CH2:14][CH:13]=[CH2:12])[NH:8][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 7850Allyl chlorideHCID 7123736-Methyl-1H-benzimidazole-2-thiol

Product 1

HCID 2151218HCID 2151218, compoundYield 64.66%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.11 g (25 mmoles) of 5-methyl-benzimidazoline-2-thione and 2.45 ml of allyl chloride are refluxed in ethanol, then the reaction mixture is evaporated. The residue is worked up according to the method described in Example 2. The residue obtained after the dichloromethane extraction is recrystallized from 7 ml acetonitrile. 3.29 g (64.66 %) of 5-methyl-2-(2-propenyl-thio)benzimidazole melting at a temperature of 128° C. are obtained.

Workup

  1. customthe reaction mixture is evaporated
  2. customThe residue obtained
  3. extractionafter the dichloromethane extraction
  4. customis recrystallized from 7 ml acetonitrile

Sources & evidence

ORD record
ord-d5cb7f9be2a24b5b825b9d08d4af9c29
Source dataset
uspto-grants-1989_03
Patent number
US04814329

Reaction notes

Loading…