Imidazole → HCID 21270050, compound

HRID 1194357Notes

Reaction equation

HRID 1194357 reaction equation
[CH3:1][N:2]([CH3:22])[CH2:3][CH2:4][C:5]([C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[NH:9][C:8]=1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:6].[NH:23]1C=CN=[CH:24]1>>[N:2]1([CH2:3][CH2:4][C:5]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]=2[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:6])[CH:1]=[CH:24][N:23]=[CH:22]1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 21270032HCID 21270032, compound

Product 1

HCID 21270050HCID 21270050, compound

Procedure

3-(Dimethylamino)-1-(2-phenyl-1H-indol-3-yl)-1-propanone was converted to the methiodide (36 g) which was then reacted with imidazole (34 g) to give a solid which was crystallised from methanol, to give the title compound (15.40 g), m.p. 206°-208°; λmax (EtOH) 255 nm (ε19,650), λmax 307.5 nm (ε12,840), identical with the material obtained in Example 3.

Workup

  1. customto give a solid which
  2. customwas crystallised from methanol

Sources & evidence

ORD record
ord-fe25f4c4455248e88f96e2862885152a
Source dataset
uspto-grants-1989_03
Patent number
US04814344

Reaction notes

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