Imidazole → HCID 21270047, compound

HRID 1194358Notes

Reaction equation

HRID 1194358 reaction equation
[CH3:1][N:2]([CH3:17])[CH2:3][CH2:4][C:5]([C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[NH:9][C:8]=1[CH3:16])=[O:6].[NH:18]1C=CN=[CH:19]1>>[N:2]1([CH2:3][CH2:4][C:5]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]=2[CH3:16])=[O:6])[CH:1]=[CH:19][N:18]=[CH:17]1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 21270027HCID 21270027, compound

Product 1

HCID 21270047HCID 21270047, compound

Procedure

3-(Dimethylamino)-1-(2-methyl-1H-indol-3-yl)-1-propanone was converted to the methiodide (1.50 g) which was then reacted with imidazole (2.67 g) to give a solid which was crystallised from methanol to give the title compound (0.65 g), m.p. 196°-197°; λmax (EtOH) 244 (ε12,920), λmax 268.5 nm (ε10,460), λmax 302.5 (ε11,400).

Workup

  1. customto give a solid which
  2. customwas crystallised from methanol

Sources & evidence

ORD record
ord-8e6f144f65d440f3b9cac09bbbd1a307
Source dataset
uspto-grants-1989_03
Patent number
US04814344

Reaction notes

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