Imidazole → HCID 21270033, compound

HRID 1194359Notes

Reaction equation

HRID 1194359 reaction equation
[CH3:1][N:2]([CH3:23])[CH2:3][CH2:4][C:5]([C:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]([CH3:16])[C:8]=1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:6].[NH:24]1C=CN=[CH:25]1>>[N:2]1([CH2:3][CH2:4][C:5]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]([CH3:16])[C:8]=2[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[O:6])[CH:1]=[CH:25][N:24]=[CH:23]1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 21270023HCID 21270023, compound

Product 1

HCID 21270033HCID 21270033, compound

Procedure

3-(Dimethylamino)-1-(1-methyl-2-phenyl-1H-indol-3-yl)-1-propanone was converted to the methiodide (5.50 g) which was then reacted with imidazole (5.50 g) to give a solid which was crystallised from ethyl acetate to give the title compound (2.91 g), m.p. 159°-162°; λmax (EtOH) 251 nm (ε19,470), λmax 307 nm (ε13,800).

Workup

  1. customto give a solid which
  2. customwas crystallised from ethyl acetate

Sources & evidence

ORD record
ord-78b852652c83468581f44ec4f724b09f
Source dataset
uspto-grants-1989_03
Patent number
US04814344

Reaction notes

Loading…