Methyl iodide → HCID 21270034, compound

Participants

Reaction Steps

A mixture of 3-(1H-imidazol-yl)-1-(2-methyl-1H-indol-3-yl)-1-propanone (148 mg), and potassium carbonate (0.7 g) in dimethylsulphoxide (5 ml) was stirred for 1 h and treated with iodomethane (0.10 g). The mixture was stirred for a further 4 h then diluted with water and extracted with ether (200 ml total). The combined organic extracts were washed with water, dried and evaporated to give the title compound which was crystallised from ethyl acetate to give a solid (80 mg), m.p. 151°-152°; λmax (EtOH) 246.5 nm (ε12,940), λmax 268.5 nm (ε8,740), λmax 306.5 nm (ε12,215).

Provenance & Evidence