反应详情

温度

50 °C

A mixture of 221.3 g (2.544 moles) of manganese dioxide and 56.9 g (0.161 mole) of alpha-methyl-1-triphenylmethyl-1H-imidazole-4-methanol dissolved in 2.5 liters of chloroform is heated under reflux for 90 minutes. The solution is then cooled to about 50° C., filtered and the chloroform is eliminated by distillation. The residue is dissolved in 400 ml of isopropyl alcohol and filtered hot on Norit. The product crystallizes upon cooling. There are obtained 32.8 g of 1-(1-triphenylmethyl-1H-imidazol-4-yl)-1-ethanone. Yield: 58% of theory; M.P.: 158°-160° C.

1. temperatureis heated
2. temperatureunder reflux for 90 minutes
3. filtrationfiltered
4. distillationthe chloroform is eliminated by distillation
5. dissolutionThe residue is dissolved in 400 ml of isopropyl alcohol
6. filtrationfiltered hot on Norit
7. customThe product crystallizes
8. temperatureupon cooling