HCID 14520339, compound → HCID 178477816, compound

Participants

Reaction Steps

50.85 g (0.1 mole) of alpha-(6-chloro-4H-1,3-benzodioxin-8-yl)-1-triphenylmethyl-1H-imidazole-4-methanol (prepared in Example 1.C.1.), dissolved in 500 ml of acetic acid, are hydrogenolyzed in the presence of 3 g of 10% palladium on carbon for 2 hours at 80° C., under a hydrogen pressure of 2.41 bars. The catalyst is then filtered off and the solvent is distilled under reduced pressure. The residue obtained is extracted three times with diethyl ether to remove the triphenylmethane formed. It is subsequently recrystallized from 50 ml of acetonitrile. 21.2 g of 4-[(4H-1,3-benzodioxin-8-yl)methyl]-1H-imidazole hydrochloride are obtained. Yield: 83% of theory; M.P.: 168°-173° C.

Provenance & Evidence