4-Fluoro-3-phenoxybenzaldehyde → HCID 54022368, compound

HRID 1194400Notes

Reaction equation

HRID 1194400 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([CH3:15])([C:12](=[O:14])[CH3:13])[CH3:11])=[CH:6][CH:5]=1)[CH3:2].[O:16]([C:23]1[CH:24]=[C:25]([CH:28]=[CH:29][C:30]=1[F:31])[CH:26]=O)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[O:16]([C:23]1[CH:24]=[C:25]([CH:26]=[CH:13][C:12](=[O:14])[C:10]([C:7]2[CH:8]=[CH:9][C:4]([O:3][CH2:1][CH3:2])=[CH:5][CH:6]=2)([CH3:11])[CH3:15])[CH:28]=[CH:29][C:30]=1[F:31])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 1100684-Fluoro-3-phenoxybenzaldehydeHCID 99905692-Butanone, 3-(4-ethoxyphenyl)-3-methyl-

Product 1

HCID 54022368HCID 54022368, compoundYield 47.7%

Procedure

In the same manner as described in (a) of (1) of Synthesis Example 2, 12.0 g of the residue was obtained by using 6.2 g of 2-(4-ethoxyphenyl)-2-methyl-3-butanone and 6.5 g of 3-phenoxy-4-fluorobenzaldehyde. The residue was purified by column chromatography on 200 g of silica gel (eluent: benzene) to give 5.8 g of 1-(3-phenoxy-4-fluorophenyl)-4-(4-ethoxyphenyl)-4-methyl-1-penten-3-one.

Workup

  1. customThe residue was purified by column chromatography on 200 g of silica gel (eluent: benzene)

Sources & evidence

ORD record
ord-f07fee767c2c4a37844be6cf9a31d5ef
Source dataset
uspto-grants-1989_03
Patent number
US04814340

Reaction notes

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