Methane → HCID 9795158, compound

Participants

Reaction Steps

6,7-Dihydroxy-3-(4-fluorophenyl)-4H-1-benzopyran-4-one (1.2 g), dissolved in a mixture of dioxan/ethanol 4:6 (40 ml), is hydrogenated for 24 h at room temperature over palladium 5% on active charcoal (0.48 g) in the presence of a few drops of conc. sulphuric acid. After filtration of the catalyst, the filtrate is evaporated to dryness under vacuum. An oil is obtained which crystallizes to give 3,4-dihydro-6,7-dihydroxy-3-(4-fluorophenyl)-2H-1-benzopyran, m.p. 135°-137°.

Provenance & Evidence