Chloroacetic Acid → HCID 54135854, compound

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Reaction Steps

NaH is dissolved in dry dimethylformamide under nitrogen atmosphere at 0°. 7,8-Dimethoxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one [cp. J. Inst. Chem. (Calcutta) 43, 234 (1971)], dissolved in dry dimethylformamide, is added slowly, then a solution of chloroacetic acid. The solution is heated at 70° for 5 h and evaporated under vacuum to about one third of its original volume. After cooling, water is added and a precipitate occurs which is filtered and crystallized in methanol to give 7,8-dimethoxy-3-(4-carboxymethoxyphenyl)-4H-1-benzopyran-4-one.

Provenance & Evidence