Ethylmorpholine → HCID 131715897, compound

Participants

Reaction Steps

360 mg (0.52 millimole) of triiodothyronine methyl ester hydrochloride and 220 mg (1.07 millimoles) of dicyclohexylcarbodiimide, dissolved in 0.5 ml of dimethylformamide, are added successively to the solution of 110 mg of methylphosphinopropionic acid (0.72 millimole) and 0.3 ml (2.35 millimoles) of N-ethylmorpholine in 2 ml of dimethylformamide with stirring, ice cooling and exclusion of moisture. The mixture is allowed to warm to room temperature with stirring, and the precipitated dicyclohexylurea is then filtered off under suction after standing for 28 hours under the exclusion of light at room temperature. The residue which remains after distilling off the solvent is precipitated repeatedly from ethanol/ether.

Provenance & Evidence