HCID 21270536, compound → HCID 86742826, compound

HRID 1194524Notes

Reaction equation

HRID 1194524 reaction equation
[CH3:1][PH:2][CH2:3][C:4]([OH:6])=O.Cl.C[O:9][C:10](=[O:30])[C@H:11]([CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=2)=[CH:18][CH:17]=1)[N:12]([I:14])[I:13]>>[CH3:1][PH:2][CH2:3][C:4]([C@@:11]([C:10]([OH:30])=[O:9])([CH2:15][C:16]1[CH:17]=[CH:18][C:19]([O:22][C:23]2[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=2)=[CH:20][CH:21]=1)[N:12]([I:13])[I:14])=[O:6]

Participants

3

Reactant 2

HCID 21270536HCID 21270536, compoundHCID 86742827HCID 86742827, compound

Product 1

HCID 86742826HCID 86742826, compound

Procedure

The compound was prepared analogously to the procedure described in examples (2) and (3). Methylphosphinoacetic acid was used in place of methylphosphinopropionic acid and diiodothyronine methyl ester hydrochloride was used in place of triiodothyronine methyl ester hydrochloride. The final product was purified by inverse phase column chromatography on silica gel RP 18 using 75% strength methanol as eluent. The unary substance of the main fraction, differing in the TLC from the starting materials, was identified by mass spectrometry as the title compound.

Workup

  1. customThe compound was prepared analogously to the procedure
  2. customThe final product was purified by inverse phase column chromatography on silica gel RP 18 using 75% strength methanol as eluent

Sources & evidence

ORD record
ord-0208063af19b4e529a003f6a516072b2
Source dataset
uspto-grants-1989_03
Patent number
US04814484

Reaction notes

Loading…