(2R)-3-Chloro-1,2-propanediol → (S)-2,3-Dihydroxy-N,N,N-trimethylpropan-1-aminium chloride

Participants

Reaction Steps

There was added 80 ml of 30 w/v % aqueous solution of trimenthylamine to 20.00 g of (R)-3-chloro-1,2-propanediol (optical purity: 100% e.e., chemical purity: 99%). After stirring for 2 hours at room temperature, the reaction mixture was evaporated to dryness to give 30.40 g of (S)-2,3-dihydroxypropyltrimethylammonium chloride.

Provenance & Evidence