1-(Dimethoxymethyl)-4-(2-methoxypropan-2-yl)benzene → 116473-61-1

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Reaction Conditions

Reaction Steps

4-(1-Methoxy-1-methylethyl)benzaldehyde dimethyl acetal (1.8 kg) and water (1.8 kg) are heated in a stirred flask for about 1 h under reflux at 87° C. The mixture is cooled to about 25° C., and the two phases are separated. The organic phase is distilled with a head pressure of 4 mbar and head temperature of 105°-108° C. 4-(1-Methoxy-1-methylethyl)benzaldehyde (1314.6 g) is obtained. HNMR: (CH3)2C-- 1.55 ppm (s), --OCH3 3.1 ppm (s), ArH 7.6 ppm (d), 7.90 ppm (d), --CHO 10.0 ppm (s). nD25 =1.5264. The yield is 97.3%.

Provenance & Evidence