Benzoyl chloride → 4-Methoxybenzophenone

Participants

Reaction Steps

To an agitated mixture of lithium chloride (3.18 g., 0.075 mole) and aluminium chloride (20 g., 0.15 mole) in dichloroethane cooled to below -10° C. was added anisole (5.41 g., 0.05 mole) and benzoyl chloride (7.03 g., 0.05 mole) in dichloroethane (10 ml). The reaction mixture was held below -10° C. for one hour then allowed to come to room temperature overnight. The 4-methoxybenzophenone produced (9.55 g., 90.1% yield) had a gas chromatograph/mass spectrometer estimated purity of over 95% with 2% ortho isomers.

Provenance & Evidence