Sulfuric Acid → HCID 86742829, compound

HRID 1194648Notes

Reaction equation

[S:1](=[O:5])(=[O:4])([OH:3])[OH:2].[CH3:6][O:7][C:8]([C@@H:10]([NH:18][C:19]([C@@H:21]([NH2:26])[CH2:22][C:23]([OH:25])=[O:24])=[O:20])[CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:9]>>[CH3:6][O:7][C:8]([C@@H:10]([NH:18][C:19]([C@@H:21]([NH2:26])[CH2:22][C:23]([OH:25])=[O:24])=[O:20])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9].[S:1]([O-:5])([O-:4])(=[O:3])=[O:2]

Participants

Reactant 2

HCID 1118Sulfuric Acid

HCID 134601Aspartame

Product 1

HCID 86742829HCID 86742829, compound

Procedure

Empty capsule and tablet unit dose blisters having five small holes drilled on both the top and bottom of each blister were utilized as the dispensing means. An aspartame sulfate solution was prepared by dissolving 1.66 g of sulfuric acid (96%) and 10.0 g of aspartame (96% pure) in 20 mls. warm distilled water. The aqueous solution was added to 250 mls. of ethanol preheated to 60° C.

Workup

temperaturewarm
distillationdistilled water
additionThe aqueous solution was added to 250 mls
custompreheated to 60° C.

Sources & evidence

ORD record: ord-e4bb4d2d28424cdab58828eca32913f4
Source dataset: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04816268

Reaction notes

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