Hydrochloric Acid → HCID 178439661, compound

Participants

Reaction Steps

A mixture of 1.04 g (2.65 mmoles) of 9-[(4-acetyl-3-hydroxy-2-n-propylphenoxy)methyl]-3-cyanomethyl-4H-pyrido[1,2-a]pyrimidin-4-one, 1.00 g (18.69 mmoles) of ammonium chloride, 1.21 g (18.61 mmoles) of sodium azide and 30 ml of dimethylformamide was heated at 100°-110° C. for 8 hours with stirring. After cooling, the resulting reaction solution was poured into ice water and then acidified with dilute hydrochloric acid. The precipitate so formed was collected by filtration and recrystallized from dimethylformamide to obtain 0.55 g (48% yield) of 9-[(4-acetyl-3-hydroxy-2-n-propylphenoxy)methyl]-3-[(1H-tetrazol-5-yl)methyl]-4H-pyrido[1,2-a]pyrimidin-4-one in the form of pale-yellow crystals. These crystals had a melting point of 250°-253° C. (dec.).

Provenance & Evidence