HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (+/-)-1-(3,4,5-Trimethoxybenzoyl)-decahydro-8-(1-pyrrolidinyl)-quinoline hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Benzoyl chloride, 3,4,5-trimethoxy- | HCID 78282 | — |
| Reactant | (+/-)-Decahydro-8-(-pyrrolidinyl)-quinoline | HCID 13983380 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | (+/-)-1-(3,4,5-Trimethoxybenzoyl)-decahydro-8-(1-pyrrolidinyl)-quinoline hydrochloride | HCID 86742835 | 36.3% |
Reaction Steps
510 mg of 3,4,5-trimethoxybenzoyl chloride and 417 mg of the product of Step C of Example 1 were reacted in ether for 40 hours at ambient temperature and the crude product obtained in the form of the base was converted into the hydrochloride as in Example 1 to obtain 319 mg of the expected product melting at ≈260° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04816465 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-026360c514754e679a282f293011c415 |
| Source note | uspto-grants-1989_03 |