HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → 3-Methyl-5-(trifluoromethyl)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | (3-Methyl-5-(trifluoromethyl)phenyl)methanol | HCID 2775612 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Methyl-5-(trifluoromethyl)benzaldehyde | HCID 23036229 | — |
Reaction Steps
A solution fo oxalyl chloride (2.8 ml) in 20 ml of CH2Cl2 is treated with a solution of dimethyl sulfoxide (DMSO)(5.0 ml) in 15 ml of CH2Cl2 at -60° C. as in Example 11 To this mixture is added the 3-trifluoromethyl-5-methylbenzyl alcohol (5.4 g) in CH2Cl2 (20 ml) followed by 20 ml of triethlyamine. Appropriate reaction conditions and work-up as in Example 11 afforded 3-trifluoro- methyl-5-methylbenzaldehyde.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04816469 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-c20a28d229b84864ba030f1b779000e1 |
| Source note | uspto-grants-1989_03 |