Thionyl Chloride → HCID 86741590, compound

Participants

Reaction Steps

161 g of 2,4-dimethoxy-5-methyl sulphonyl-benzoic acid is reacted. 590 g of thionyl chloride, 5 drops of dimethylformamide and about half of the organic acid are placed in a 2 liter flask fitted with a reflux condenser. The resultant suspension is heated in a water bath at 55° C. for about 5 minutes. The second half of the organic acid is added and heating is continued for 20 minutes at 60°-65° C. then for 45 minutes at 70°-75° C. The medium becomes fluid and turns yellow. The acid dissolves gradually, while the acid chloride begins to crystallize. When the reaction is over the excess thionyl chloride is distilled to constant weight, finishing up under vacuum.

Provenance & Evidence